Jovanka Gencel-Augusto

Dec 7, 2023 | cell.com | Jovanka Gencel-Augusto |Trever G. Bivona |Chan-Zuckerberg Biohub

Although growth receptor pathways commonly activate similar pathways, Lv et al. show that EGF signaling represses m6A levels in contrast to induction by PDGF. EGFR blocks ALKBH5 nuclear export, increasing m6A eraser function and suppression of ferroptosis through glutathione production. ALKBH5 inhibitors enhance the anti-tumor efficacy of EGFR or glutathione inhibitors.

Jun 10, 2023 | mdpi.com | Wei Wu |Trever G. Bivona |Jovanka Gencel-Augusto

Abstract: Simple SummaryLong non-coding RNAs (LncRNAs) are non-protein coding molecules longer than 200 nucleotides. They play essential roles in normal cell function and development, and can contribute to diseases such as cancer when dysregulated. Although lncRNAs have oncogenic or tumor-suppressive properties in lung cancer and can serve as stable biomarkers, this is still an understudied field.