Juan Manuel Leyva-Castillo

Jul 22, 2024 | biorxiv.org | Juan Manuel Leyva-Castillo |Raif S. Geha

AbstractAtopic dermatitis (AD) commonly precedes food allergy and asthma in the atopic march. Epicutaneous (EC) sensitization in mice with ovalbumin (OVA) results in allergic skin inflammation that mimics AD and promotes food anaphylaxis or asthma following a gastric or intranasal challenge with OVA, respectively. Using our mouse model of EC sensitization with OVA we evaluate whether anti-IL-4Ra; blocking antibody improve allergic skin inflammation and impact the atopic march.

Oct 12, 2023 | cell.com | Juan Manuel Leyva-Castillo

Highlights Red meat allergy is linked to exposure to alpha-Gal epitopes found in the saliva of ticks and hence known as the alpha-Gal syndrome. Alpha-Gal epitopes are found in the saliva of the Lone star tick, Amblyomma americanum, and the alpha-Gal syndrome is predominantly associated with exposure to A. americanum tick bites in the USA.