Judith P. Klinman

3 weeks ago | pubs.acs.org | Judith P. Klinman |Susan Miller

1. IntroductionClick to copy section linkSection link copied!Expanding our understanding of the underlying physical properties of enzyme function provides new design principles. Findings from experimental probes are essential to guide future computational predictions. After almost 80 years, Pauling’s proposal of “enhanced binding between enzymes and their activated substrate” (1,2) remains the dominant model for the origin of enzyme catalysis.

3 weeks ago | dx.doi.org | Judith P. Klinman |Susan Miller

1. IntroductionClick to copy section linkSection link copied!Expanding our understanding of the underlying physical properties of enzyme function provides new design principles. Findings from experimental probes are essential to guide future computational predictions. After almost 80 years, Pauling’s proposal of “enhanced binding between enzymes and their activated substrate” (1,2) remains the dominant model for the origin of enzyme catalysis.