Jujun Zhou

Sep 9, 2024 | digitalcommons.library.tmc.edu | Jujun Zhou |John Horton |Gundeep kaur |Qin Chen

Home > UTHealth > GSBS > Faculty and Staff Publications > 1073 Faculty and Staff Publications Journal of Biological Chemistry Animals, DNA Methylation, DNA-Cytosine Methylases, Mammals, Rotifera DOWNLOADS Included in Bioinformatics Commons, Biomedical Informatics Commons, Medical Sciences Commons, Oncology Commons COinS...

Aug 14, 2024 | digitalcommons.library.tmc.edu | John Horton |Jujun Zhou |Qin Chen |Xing Zhang

Publication Date2-1-2023JournalJournal of Biological ChemistryAbstractThe N-terminal half of PHF2 harbors both a plant homeodomain (PHD) and a Jumonji domain. The PHD recognizes both histone H3 trimethylated at lysine 4 and methylated nonhistone proteins including vaccinia-related kinase 1 (VRK1). The Jumonji domain erases the repressive dimethylation mark from histone H3 lysine 9 (H3K9me2) at select promoters.

Apr 3, 2024 | biorxiv.org | Jujun Zhou |Qin Chen |Ren Ren |Jie Yang

AbstractDNA methylation, as exemplified by cytosine-C5 methylation in mammals and adenine-N6 methylation in bacteria, is a crucial epigenetic mechanism driving numerous vital biological processes. Developing non-nucleoside inhibitors to cause DNA hypomethylation is a high priority, in order to treat a variety of significant medical conditions without the toxicities associated with existing cytidine-based hypomethylating agents. In this study, we have characterized fifteen quinoline-based analogs.