Julia M Heckel

Feb 22, 2024 | elifesciences.org | Samuel Gonzalez |Taylor Reid |Julia M Heckel |Rebecca R Goldblum

Editor's evaluation This paper represents an important study for the microtubule cytoskeleton research community. By employing computational simulation, cell-free biophysical assays, and live-cell imaging, Gonzalez et al. convincingly reveal a mechanistic insight into the EB1 tip-tracking activity at the growing microtubule plus ends, preferential binding of GTP- over GDP-microtubule protofilaments does not fully explain the plus tip tracking of EB1.