Julien Lescar

Nov 1, 2023 | nature.com | Nikhil Kumar Tulsian |Jianqing Lin |Kiren Purushotorman |Bei Wang |Julien Lescar |Cheng-I Wang | +1 more

AbstractThe changing landscape of SARS-CoV-2 Spike protein is linked to the emergence of variants, immune-escape and reduced efficacy of the existing repertoire of anti-viral antibodies. The functional activity of neutralizing antibodies is linked to their quaternary changes occurring as a result of antibody-Spike trimer interactions. Here, we reveal the conformational dynamics and allosteric perturbations linked to binding of novel human antibodies and the viral Spike protein.