Junhua Pan

Aug 1, 2024 | nature.com | Pan Yang |Wanyu Li |Xiaoyi Fan |Junhua Pan |Haley Varnum |Himanish Basu | +1 more

AbstractEastern equine encephalitis virus (EEEV) is the most virulent alphavirus that infects humans, and many survivors develop neurological sequelae, including paralysis and intellectual disability. Alphavirus spike proteins comprise trimers of heterodimers of glycoproteins E2 and E1 that mediate binding to cellular receptors and fusion of virus and host cell membranes during entry.

Nov 14, 2023 | biorxiv.org | Pan Yang |Wanyu Li |Junhua Pan |Xiaoyi Fan

AbstractAlphaviruses are arthropod-borne enveloped RNA viruses that include several important human pathogens with outbreak potential. Among them, eastern equine encephalitis virus (EEEV) is the most virulent, and many survivors develop neurological sequelae, including paralysis and intellectual disability.