Junta Imai

Apr 25, 2024 | onlinelibrary.wiley.com | Junta Imai

Type 1 interferon (IFN) transcriptional signatures in pancreatic islets were previously reported in patients with type 1 diabetes1. Although viral infections in islets are speculated to trigger IFN responses, the viruses inducing these responses have not as yet been identified. Double-stranded ribonucleic acids (RNAs) (dsRNAs), both exogenous and endogenous, are powerful activators of dsRNA sensors that trigger type 1 IFN responses.

Apr 1, 2024 | nature.com | Junta Imai |Yosuke M. Morizawa |Tomohito Izumi |Shinichiro Hosaka |Kei Takahashi |Kuniyasu Niizuma | +2 more

Correction to: Nature Biomedical Engineering https://doi.org/10.1038/s41551-023-01113-2, published online 9 November 2023. This article was originally published under the standard Springer Nature license (© The Author(s), under exclusive licence to Springer Nature Limited). It is now available as an open-access paper under a Creative Commons Attribution 4.0 International license, © The Author(s). The error has been corrected in the HTML and PDF versions of the article.

Nov 8, 2023 | nature.com | Junta Imai |Yosuke M. Morizawa |Tomohito Izumi |Shinichiro Hosaka |Kei Takahashi |Kuniyasu Niizuma | +2 more

AbstractThe enhancement of insulin secretion and of the proliferation of pancreatic β cells are promising therapeutic options for diabetes. Signals from the vagal nerve regulate both processes, yet the effectiveness of stimulating the nerve is unclear, owing to a lack of techniques for doing it so selectively and prolongedly.

Jun 14, 2023 | nature.com | Junta Imai |Kei Takahashi

AbstractCell proliferation processes play pivotal roles in timely adaptation to many biological situations. Herein, we establish a highly sensitive and simple strategy by which time-series showing the proliferation of a targeted cell type can be quantitatively monitored in vivo in the same individuals. We generate mice expressing a secreted type of luciferase only in cells producing Cre under the control of the Ki67 promoter.