Justin Cotton

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Mucus production, host-microbiome interactions, hormone sensitivity, and innate immune responses modeled in human cervix chips - Nature Communications

May 28, 2024 | nature.com | Justin Cotton |Siyu S. Chen |Viktor Horváth |Anna Stejskalová |Sanjid Shahriar |Yixuan Xie | +1 more

AbstractModulation of the cervix by steroid hormones and commensal microbiome play a central role in the health of the female reproductive tract. Here we describe organ-on-a-chip (Organ Chip) models that recreate the human cervical epithelial-stromal interface with a functional epithelial barrier and production of mucus with biochemical and hormone-responsive properties similar to living cervix.

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