Justin D Lathia

Sep 4, 2024 | nature.com | Justin D Lathia

NEWS AND VIEWS 03 September 2024 The human brain is usually considered to be beyond the reach of most immune cells. However, analysis of people who have brain tumours has revealed tumour-targeting T cells of the immune system in skull bones near the cancer site. The brain has historically been considered to be immune-privileged, meaning that few immune cells reside in or infiltrate the brain, even in the case of disease.

Feb 1, 2024 | jci.org | András K. Ponti |Daniel Silver |Christopher Hine |Justin D Lathia

AbstractA major challenge in treating patients with glioblastoma is the inability to eliminate highly invasive cells with chemotherapy, radiation, or surgical resection. As cancer cells face the issue of replicating or invading neighboring tissue, they rewire their metabolism in a concerted effort to support necessary cellular processes and account for altered nutrient abundance. In this issue of the JCI, Garcia et al.

Oct 19, 2023 | cell.com | Justin D Lathia

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Aug 23, 2023 | cell.com | Justin D Lathia

HighlightsOngoing research into drivers of cancer have revealed that protumorigenic pathways have pleiotropic and overlapping effects. In glioblastoma, phosphatase and tensin homolog (PTEN) loss of function, hypoxia, and interleukin-6 (IL-6)/signal transducer and activator of transcription 3 (STAT3) signaling exemplify the broad effects of cancer drivers on multiple aspects of cell-intrinsic and tumor microenvironment homeostatic defenses.