Jyoti Goad

Nov 1, 2024 | biorxiv.org | Jyoti Goad |Amina Khan |Rutuja Deshmukh |Michelle M Halstead

AbstractFor a brief but critical period post-fertilization, the mammalian embryo is entirely dependent on maternal products inherited from the oocyte. Previous research showed that oocyte-specific loss of Med12, an X-linked gene and Mediator complex subunit, leads to female sterility despite normal folliculogenesis and ovulation. Here, we show that loss of maternal Med12 has minimal effect on the oocyte transcriptome and does not manifest in embryonic lethality until post-implantation.