K. Tae

Featured in: Favicon

Articles

Biomolecules | Free Full-Text | Development of an Anti-HER2 Single-Chain Variable Antibody Fragment Construct for High-Yield Soluble Expression in Escherichia coli and One-Step Chromatographic Purification

Oct 11, 2023 | mdpi.com | K. Tae |Boram Kim |Junmin Cho |Kyu Tae Byun

1. IntroductionSince hybridoma technology was developed in the mid-1970s, immunoglobulin G (IgG)-based monoclonal antibodies (mAbs) have served as an invaluable asset for developing antibody-based therapeutic and diagnostic agents for various diseases. Advances in recombinant protein technology have led to rapid progress in the application of antibody engineering, including antibody-drug conjugates (ADCs), bispecific antibodies (biAbs), and diverse scaffolds of antibody fragments (AbFs) [1,2,3,4].

Try JournoFinder For Free

Search and contact over 1M+ journalist profiles, browse 100M+ articles, and unlock powerful PR tools.