Kaiming Zhang

Aug 1, 2024 | onlinelibrary.wiley.com | Ruifeng Liu |Luyao Zhang |Kaiming Zhang

H3K27 histone 3 lysine 27 H3K4 histone 3 lysine 4 H3K9 histone 3 lysine 9 IL-17a interleukin-17A miR-210 microRNA-210 PBMCs peripheral blood mononuclear cells 1 INTRODUCTION Psoriasis is a prevalent, immune-mediated and chronic systemic inflammatory illness that can occur at any age and has an increased risk of comorbidities such as arthritis, autoimmune diseases, cardiovascular disease, obesity and malignancy.1, 2 Psoriasis imposes a substantial disease burden on patients, including...

Jul 30, 2024 | nature.com | Xiaolong Zhao |Kaiming Zhang

AbstractMuB is a non-specific DNA-binding protein and AAA+ ATPase that significantly influences the DNA transposition process of bacteriophage Mu, especially in target DNA selection for transposition. While studies have established the ATP-dependent formation of MuB filament as pivotal to this process, the high-resolution structure of a full-length MuB protomer and the underlying molecular mechanisms governing its oligomerization remain elusive.

Jan 1, 2024 | nature.com | Yang Du |Kaiming Zhang

AbstractHistamine receptors are a group of G protein-coupled receptors (GPCRs) that play important roles in various physiological and pathophysiological conditions. Antihistamines that target the histamine H1 receptor (H1R) have been widely used to relieve the symptoms of allergy and inflammation.