Kalpana Manthiram

2 months ago | nature.com | Kalpana Manthiram |Qin Xu

Lymphoid tissues in the upper respiratory tract contain immune cells that are crucial for local immunity. An analysis of adenoid tissue from individuals during and after SARS-CoV-2 infection is used to characterize tissue immune responses.

Apr 12, 2024 | nature.com | Hirotsugu Oda |Kalpana Manthiram |Pallavi Pimpale Chavan |Shuichiro Nakabo |Mariël Swart |Nisa Celik | +22 more

AbstractThe linear ubiquitin assembly complex (LUBAC) consists of HOIP, HOIL-1 and SHARPIN and is essential for proper immune responses. Individuals with HOIP and HOIL-1 deficiencies present with severe immunodeficiency, autoinflammation and glycogen storage disease. In mice, the loss of Sharpin leads to severe dermatitis due to excessive keratinocyte cell death.

Jul 19, 2023 | pubmed.ncbi.nlm.nih.gov | Kalpana Manthiram

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