Kamil Nosol

Nov 9, 2023 | nature.com | Hongtao Liu |Rossitza N. Irobalieva |Julia Kowal |Dongchun Ni |Kamil Nosol |Henning Stahlberg | +2 more

AbstractBSEP (ABCB11) is an ATP-binding cassette transporter that is expressed in hepatocytes and extrudes bile salts into the canaliculi of the liver. BSEP dysfunction, caused by mutations or induced by drugs, is frequently associated with severe cholestatic liver disease. We report the cryo-EM structure of glibenclamide-bound human BSEP in nanodiscs, revealing the basis of small-molecule inhibition.