Karen Agaronyan

Aug 12, 2024 | biorxiv.org | Jooyoung Kim |Yifan Yuan |Karen Agaronyan |Amy Zhao

AbstractHost response aimed at eliminating the infecting pathogen, as well as the pathogen itself, can cause tissue injury. Tissue injury leads to the release of a myriad of cellular components including mitochondrial DNA, which the host senses through pattern recognition receptors. How the sensing of tissue injury by the host shapes the anti-pathogen response remains poorly understood.

Mar 6, 2024 | biorxiv.org | Jooyoung Kim |Yifan Yuan |Karen Agaronyan |Amy Zhao

AbstractHost response aimed at eliminating the infecting pathogen, as well as the pathogen itself, can cause tissue injury. Tissue injury leads to the release of a myriad of cellular components including mitochondrial DNA, which the host senses through pattern recognition receptors. How the sensing of tissue injury by the host shapes the anti-pathogen response remains poorly understood.