Karen H Seal

2 months ago | jamanetwork.com | William Becker |Karen H Seal |David Nelson

Buprenorphine, Pain, and Opioid Use in Patients Taking High-Dose Long-Term Opioids: A Randomized Clinical Trial Key PointsQuestion  For patients with moderate to severe chronic pain despite high-dose, long-term opioid therapy, does having the option to switch to buprenorphine compared with not having the option result in more pain improvement and opioid dosage reduction?

2 months ago | jamanetwork.com | Michael Incze |Timothy Anderson |William Becker |Karen H Seal

Integrating Buprenorphine Into Chronic Pain Treatment—Putting the Choice in VOICE Buprenorphine, Pain, and Opioid Use in Patients Taking High-Dose Long-Term Opioids William C. Becker, MD; Karen H. Seal, MD, MPH; David B. Nelson, PhD; Beth M. DeRonne, PharmD; Allyson M. Kats, MS; Benjamin J. Morasco, PhD; Joseph W. Frank, MD, MPH; Una E. Makris, MD, MSc; Jacob T. Painter, PharmD, MBA, PhD; Kelli D. Allen, PhD; Amanda S. Mixon, MD, MS, MSPH; Amy Bohnert, PhD; Thomas E.