Karen Ling

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Targeting nonsense-mediated RNA decay does not increase progranulin levels in the Grn R493X mouse model of frontotemporal dementia

Mar 9, 2023 | journals.plos.org | Denise Smith |Michael Niehoff |Karen Ling |Paymaan Jafar-Nejad

Fig 2. IP administration of ASOs targeting NMD of the GrnR493X mRNA does not increase Grn mRNA levels in the livers and spleens. qPCR results from livers and spleens of mice following a series of four IP administrations of 50 mg/kg ASO. (A) mRNA levels are presented relative to levels in tissues of wild-type mice that received control ASO. (B) mRNA levels in wild-type mice.

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