Karen M. Wai

Oct 31, 2024 | jamanetwork.com | Shreya Shah |Jared T. Sokol |Karen M. Wai

Use of Artificial Intelligence–Based Detection of Diabetic Retinopathy in the US Vision loss from diabetic retinopathy (DR) is largely preventable, but less than two-thirds of patients with type 1 or type 2 diabetes undergo an annual eye examination.1 FDA-approved systems like LumineticsCore (formerly IDx-DR, Digital Diagnostics) and EyeArt (Eyenuk) analyze retinal fundus images for more than mild DR with fairly high sensitivity (87.2% and 96.0%, respectively) and specificity (90.7% and...

Mar 1, 2024 | journals.healio.com | Brian Chhoy |Karen M. Wai |Theodore Leng

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Jan 5, 2024 | journals.healio.com | Karen M. Wai |Theodore Leng |Brian Chhoy

IntroductionFibroblast growth factor receptors (FGFR) are a family of receptor tyrosine kinases involved in cell proliferation, cell migration, cell differentiation, and cell apoptosis. Overexpression of FGFR can cause abnormal cancer cell proliferation in cancers such as breast, glioblastoma, and hepatocellular cell carcinoma, and is thus the target of many chemotherapy agents. This class of drugs shows promise in targeted anti-cancer therapy.