-
1 week ago | 
nature.com | Karen O’Leary
RESEARCH HIGHLIGHT 29 May 2025 Researchers studied the antibody library of a venom-immune person with extensive snakebite exposure — and generated a three-agent, broadly neutralizing cocktail that protected mice against venoms from high-priority species.
-
1 week ago | 
nature.com | Karen O’Leary
RESEARCH HIGHLIGHT 29 May 2025 GLP-1 receptor agonist semaglutide significantly outperformed placebo in an ongoing phase 3 trial, showing reductions in steatohepatitis and liver fibrosis, in addition to cardiometabolic benefits. Metabolic dysfunction–associated steatohepatitis (MASH) is a form of liver disease that can progress to cirrhosis and hepatocellular carcinoma, but strategies for treating MASH are lacking.
-
2 weeks ago | 
nature.com | Karen O’Leary
RESEARCH HIGHLIGHT 22 May 2025 In a phase 2 trial, complete responses to neoadjuvant dostarlimab allowed most patients with early-stage solid tumors to avoid surgery, which allowed preservation of affected organs. Standard treatment for most early-stage solid tumors involves complete surgical resection.
-
3 weeks ago | 
nature.com | Karen O’Leary
RESEARCH HIGHLIGHT 16 May 2025 Three translational studies reveal elevated mitochondrial metabolism as a driver of age-related clonal hematopoiesis and suggest that targeting this process — for example, with metformin — could reduce the risk of associated diseases. Clonal hematopoiesis (CH) is an age-related process characterized by mutations in hematopoietic stem/progenitor cells (HSPCs), most commonly in the DNMT3A gene.
-
3 weeks ago | 
nature.com | Karen O’Leary
RESEARCH HIGHLIGHT 14 May 2025 A modeling study predicts a resurgence of previously eliminated infectious diseases, including measles, rubella, poliomyelitis and diphtheria, if current child vaccination rates continue to fall — with measles being the first to reach endemic levels. Childhood vaccination rates in the USA continue to fall.
-
1 month ago | 
nature.com | Karen O’Leary
RESEARCH HIGHLIGHT 30 April 2025 Neonatal antibiotic exposure was found to negatively impact vaccine responses, probably mediated by decreased Bifidobacterium levels — which highlights potential strategies for enhancing vaccine efficacy in infants. Global immunization programs save millions of lives annually, yet individual responses to vaccines vary and may be suboptimal in certain high-risk populations.
-
1 month ago | 
nature.com | Karen O’Leary
RESEARCH HIGHLIGHT 28 April 2025 The polygenic score, based on analysis of DNA from a saliva sample, led to the detection of more cancers than would have been found with standard screening pathways. Prostate cancer is one of the most common cancers, and early detection has a huge impact on prognosis.
-
1 month ago | 
nature.com | Karen O’Leary
RESEARCH HIGHLIGHT 14 April 2025 The first pig liver to be transplanted into a human (in this case, a brain-dead recipient) showed sustained function without rejection — marking another step toward xenotransplantation as a viable approach to addressing the organ-shortage crisis. Since 2022, there have been successful cases in which porcine hearts and kidneys have been transplanted into living and brain-dead humans.
-
2 months ago | 
nature.com | Karen O’Leary
RESEARCH HIGHLIGHT 28 March 2025 Foreign aid sanctions reverse progress on child and maternal health and increase mortality rates, according to an analysis of three decades’ worth of data from 113 countries. Sanctions have long been used as a geopolitical tool to help promote human rights and democracy, and to discourage war.
-
2 months ago | 
nature.com | Karen O’Leary
RESEARCH HIGHLIGHT 26 March 2025 Using a novel federated learning approach, organizations can pool resources to develop better drug-discovery AI models — without sharing any private data. In many fields of research, including drug discovery, the lack of sufficient high-quality data to train models is a major bottleneck in the development of impactful artificial intelligence (AI) tools.
