Karl-Heinz Herzig

Jan 6, 2024 | nature.com | Anna Ulrich |John Wharton |Inês Cebola |Marjo-Riitta Järvelin |Karl-Heinz Herzig |Luke Howard | +7 more

AbstractPulmonary arterial hypertension (PAH) is characterised by pulmonary vascular remodelling causing premature death from right heart failure. Established DNA variants influence PAH risk, but susceptibility from epigenetic changes is unknown. We addressed this through epigenome-wide association study (EWAS), testing 865,848 CpG sites for association with PAH in 429 individuals with PAH and 1226 controls.