Karla M. Neugebauer

New Haven

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Articles

Rapid folding of nascent RNA regulates eukaryotic RNA biogenesis

Mar 25, 2025 | cell.com | Leonard Schärfen |Isaac W. Vock |Matthew Simon |Karla M. Neugebauer

KeywordsRNA structuretranscription elongationeukaryotic RNA polymerasespolymerase exit channelnascent RNAco-transcriptional RNA processingRNA base pairingU2 snRNARNA helicasepre-rRNA processingRNA chemical probingtranscriptome-wide structure probingGet full text accessLog in, subscribe or purchase for full access. References1. Girbig, M. ∙ Misiaszek, A.D. ∙ Müller, C.W.Structural insights into nuclear transcription by eukaryotic DNA-dependent RNA polymerasesNat. Rev. Mol. Cell Biol. 2022; 23:603-6222.
Emerging and re-emerging themes in co-transcriptional pre-mRNA splicing

Oct 3, 2024 | cell.com | Karla M. Neugebauer

References1. Li, Y. ∙ Wang, Q. ∙ Xu, Y. ... Structures of co-transcriptional RNA capping enzymes on paused transcription complexNat. Commun. 2024; 15:46222. Ghosh, A. ∙ Lima, C.D.Enzymology of RNA cap synthesisWiley Interdiscip. Rev. RNA. 2010; 1:152-1723. Martinez-Rucobo, F.W. ∙ Kohler, R. ∙ van de Waterbeemd, M. ... Molecular Basis of Transcription-Coupled Pre-mRNA CappingMol. Cell. 2015; 58:1079-10894. Rambout, X.
How cell biology can save the planet - Nature Cell Biology

Jan 16, 2024 | nature.com | Karla M. Neugebauer

Climate change affects us all, and tackling it requires a concerted effort, but it isn’t always evident how cell biologists’ work can impact climate change. Here, I share my experience addressing climate change as a molecular cell biologist and educator. Today, many 17-year-olds urgently want to save the planet from the disastrous effects of global warming. They wonder why they should go to college.
Biochemists face the climate challenge

Sep 14, 2023 | asbmb.org | Karla M. Neugebauer

Everyone knows coral bleaching occurs when seawater gets hot. Biochemists ask: How? Corals die when their photosynthetic algal symbionts experience heat stress and exude hydrogen peroxide, causing coral tissue to expel the algae. Thus, coral bleaching is a biochemical process that we can understand and engage with, imagining new solutions to climate changes that degrade our planet. Abstract submission begins Sept. 14. If you submit by Oct. 12, you'll get a decision by Nov. 1.