Karthik Rajasekaran

May 23, 2024 | jamanetwork.com | Deepak Lakshmipathy |Christian Fritz |Beatrice Go |Karthik Rajasekaran

Key PointsQuestion  How accurate is salivary circulating tumor human papillomavirus DNA (ctHPV DNA) in detecting HPV-related oropharyngeal (OP) cancer? Findings  In this bivariate random effects meta-analysis, 6 articles with moderate heterogeneity comprising 263 patients were included, and pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio values demonstrated the test to be more specific than sensitive.

Apr 10, 2024 | onlinelibrary.wiley.com | Praneet Kaki |Doreen Lam |Neel R. Sangal |Karthik Rajasekaran

1 INTRODUCTION Since 2005, transoral robotic surgery (TORS) has provided head and neck (H&N) surgeons with a minimally invasive technique to resect tumors of the oropharynx and oral cavity.1 In addition to facilitating access to hard-to-reach anatomic sites that otherwise require an open, mandible splitting approach with significant morbidity, TORS reduces complications and shortens recovery time compared with nonrobotic transoral approaches for comparative tumors.2, 3 Traditionally, TORS...

Apr 4, 2024 | jamanetwork.com | Neel R. Sangal |Ashna Aggarwal |Karthik Rajasekaran |Doreen Lam

Preoperative Circulating Tumor HPV DNA and Oropharyngeal Squamous Cell Disease Key PointsQuestion  What is the association of preoperative circulating tumor human papillomavirus (HPV) DNA levels with disease burden in patients with HPV-associated oropharyngeal squamous cell carcinoma who have undergone transoral robotic surgery?

Dec 8, 2023 | onlinelibrary.wiley.com | Christian Fritz |Stylianos Monos |Kush Panara |Karthik Rajasekaran

Objective To characterize adverse events, provide a safety profile, and understand patient outcomes after complications arising from LigaSure and Harmonic use in the head and neck region. Methods Retrospective analysis of adverse events from the Manufacturer and User Facility Device Experience (MAUDE) between January 2013 and 2023. Results A total of 158 LigaSure and 159 Harmonic events were extracted. There were significantly more reports of Harmonic device overheating (6.9% vs.

Oct 16, 2023 | nature.com | Corey Chan |MacLean P. Nasrallah |Yin P. Hung |Maria Martinez-Lage |Peter M. Sadow |Karthik Rajasekaran

AbstractThe surgical resection of solid tumours can be enhanced by fluorescence-guided imaging. However, variable tumour uptake and incomplete clearance of fluorescent dyes reduces the accuracy of distinguishing tumour from normal tissue via conventional fluorescence intensity-based imaging.