Karuna Dixit

Aug 28, 2024 | nature.com | Jae Kyu Ryu |Zhaoqi Yan |Mauricio Montano |Karuna Dixit |Rahul Suryawanshi |Yusuke Matsui | +10 more

AbstractLife-threatening thrombotic events and neurological symptoms are prevalent in COVID-19 and are persistent in patients with long COVID experiencing post-acute sequelae of SARS-CoV-2 infection1,2,3,4. Despite the clinical evidence1,5,6,7, the underlying mechanisms of coagulopathy in COVID-19 and its consequences in inflammation and neuropathology remain poorly understood and treatment options are insufficient.

Apr 30, 2024 | elifesciences.org | Xiao-Ru Chen |Karuna Dixit |Yuan Yang |Mark McDermott

Editor's evaluation Pin1 is an essential prolyl cis/trans isomerase which has attracted considerable attention as this enzyme family is implicated in cancer and neurodegenerative diseases. Here, authors provide compelling evidence that Pin1 modulates the activity of an important cell signaling kinase, Protein Kinase C by a non-catalytic mechanism. This result suggests a new mode of Pin1 action, regulating the cellular stability of the kinase via a chaperone-like activity.

Sep 20, 2023 | biorxiv.org | Xiao-Ru Chen |Karuna Dixit |Yuan Yang |Mark McDermott

AbstractRegulated hydrolysis of the phosphoinositide phosphatidylinositol(4,5)-bis-phosphate to diacylglycerol and inositol-1,4,5-P3 defines a major eukaryotic pathway for translation of extracellular cues to intracellular signaling circuits. Members of the lipid-activated protein kinase C isoenzyme family (PKCs) play central roles in this signaling circuit.