Katarzyna Bulek

Nov 6, 2024 | digitalcommons.library.tmc.edu | Quanri Zhang |Weiwei Liu |Katarzyna Bulek |Han Wang

BACKGROUND: Macrophage-inducible C-type lectin (Mincle) is expressed on hepatic macrophages and senses ethanol (EtOH)-induced danger signals released from dying hepatocytes and promotes IL-1β production. However, it remains unclear what and how EtOH-induced Mincle ligands activate downstream signaling events to mediate IL-1β release and contribute to alcohol-associated liver disease (ALD).