Katarzyna Hencel

Sep 16, 2023 | biorxiv.org | Aykut Shen |Katarzyna Hencel |Matthew Parker |Robyn Scott

Abstractpre-mRNA splicing is a critical feature of eukaryotic gene expression. Many eukaryotes use cis-splicing to remove intronic sequences from pre-mRNAs. In addition to cis-splicing, many organisms use trans-splicing to replace the 5′ ends of mRNAs with a non-coding spliced-leader RNA. Both cis- and trans-splicing rely on accurately recognising splice site sequences by spliceosomal U snRNAs and associated proteins.