Katelyn M Polemi

2 months ago | biorxiv.org | Rachel Morgan |Anagha Tapaswi |Katelyn M Polemi |Jenna Miller

AbstractLead (Pb) continues to be a public health burden, in the US and around the world, and yet the effects of historical and current exposure levels on neurogenesis are not fully understood. Here we examine the effects of a range of environmentally relevant Pb concentrations (0.16uM, 1.26uM, and 10uM Pb) relative to control on neural differentiation in the SH-SY5Y cell model. Pb exposure began on Day 5 and continued throughout differentiation at Day 18.

Nov 3, 2024 | biorxiv.org | Rachel Morgan |Anagha Tapaswi |Katelyn M Polemi |Elizabeth C Tolrud

AbstractLead (Pb) causes learning and memory impairments, but the molecular effects of continuous, environmentally relevant levels of exposure on key neurodevelopmental processes are not fully characterized. Here we examine the effects of a range of environmentally relevant Pb concentrations (0.16μM, 1.26μM, and 10μM Pb) relative to control on neural differentiation in the SH-SY5Y cell model.