Katelyn M. Spillane

Nov 19, 2024 | cell.com | Jana Obajdin |Daniel Larcombe-Young |Maya Glover |Caroline Hull |Katie Flaherty |Ge Tan | +13 more

Keywordschimeric antigen receptorNKG2DDap10Dap12adaptorIntroductionNKG2D is expressed by natural killer (NK) cells, CD8+ αβ T cells, γδ T cells, invariant NKT cells, and some CD4+ T cell subsets.1 It mediates the recognition of cells that express any of the eight NKG2D ligands (NKG2DLs), namely MHC class I polypeptide-related sequence (MIC)A/B and UL16-binding protein (ULBP)1–6.

Aug 2, 2023 | mdpi.com | Ge Tan |Katelyn M. Spillane |John Maher

Abstract: Simple SummaryThe immune system provides surveillance measures to identify and remove damaged cell types at an early stage. One important example involves the NKG2D receptor, which is expressed on a range of white blood cells. In humans, NKG2D binds to a family of eight proteins known as NKG2D ligands. NKG2D ligands are generally absent from the surfaces of healthy cells.