Katharine Chen

1 month ago | nature.com | Patrick J Nugent |Heungwon Park |James Yelland |Sayantani Sinha |Katharine Chen |Andrew Hsieh

AbstractRNAs undergo a complex choreography of metabolic processes that are regulated by thousands of RNA-associated proteins. Here we introduce ReLiC, a scalable and high-throughput RNA-linked CRISPR approach to measure the responses of diverse RNA metabolic processes to knockout of 2,092 human genes encoding all known RNA-associated proteins.