Katharine White

Aug 9, 2024 | jbc.org | South Bend |Notre Dame |Lindsey B. Harris |Katharine White

KeywordsIntracellular pHmetabolismglycolysispyruvatelactateNotch1 signalingIntroductionNormal epithelial cells have an intracellular pH (pHi) of ∼7.2, but transient changes in pHi (6.8- 7.6) have been shown to regulate cell behaviors, including cell migration (1), proliferation (2, 3), and differentiation (4) (Figure 1A).