Katherine Vaidya

Dec 23, 2024 | onlinelibrary.wiley.com | Katherine Vaidya |Mn Usa |Michael Regan

Pooled screening allows for high-throughput evaluation of nanoparticle (NP) properties that mediate successful delivery outcomes and enable the generation of large datasets for subsequent intersystem analyses.1-8 Nucleic acid barcodes have been primarily applied to pooled NP screening due to their low detection limits and large number of possible combinations.9 They have been used to screen large libraries of lipid nanoparticles (LNPs) to determine tissue accumulation and functional delivery,...

Sep 26, 2024 | biorxiv.org | Michael Regan |James Lin |Katherine Vaidya |Jenna Houle

AbstractWe report the development of a small molecule-based barcoding platform for pooled screening of nanoparticle delivery. Using aryl halide-based tags (halocodes), we achieve high-sensitivity detection via gas chromatography coupled with mass spectrometry or electron capture. This enables barcoding and tracking of nanoparticles with minimal halocode concentrations and without altering their physicochemical properties.