Kathleen M. Mulvaney

Jan 7, 2025 | jbc.org | Kathleen M. Mulvaney |William Sellers |Eric S. Fischer

IntroductionArginine methylation is a post-translational modification that results in the addition of one or two methyl groups to the guanidino moiety of arginine from the cofactor S-Adenosyl-L-Methionine (SAM) (1-3). Among the three types of protein arginine methyltransferases (PRMTs), type II PRMTs are responsible for installing symmetric dimethyl-arginine (SDMA) marks (4, 5). Type II PRMTs include PRMT5 and PRMT9, where PRMT5 is the main writer of cellular SDMA (6).