Katrin Gunka

Mar 14, 2024 | enviromicro-journals.onlinelibrary.wiley.com | Johanna Rapp |Iker Irisarri |Katrin Gunka |Hannes Link

INTRODUCTION Glutamate is the major amino group donor in any living organism due to delivering 80–88% of the nitrogen for the synthesis of nitrogen-containing molecules (Ikeda et al., 1996; Magasanik, 1996, 2003; Wohlheuter et al., 1973). Beside its role as a precursor for the synthesis of the glutamate family amino acids, such as glutamine, arginine, and proline, it is also directly incorporated into proteins.

Nov 10, 2023 | biorxiv.org | Johanna Rapp |Iker Irisarri |Katrin Gunka |Mohammad SY. Mardoukhi

AbstractGlutamate serves as the major cellular amino group donor. In Bacillus subtilis, glutamate is synthesized by the combined action of the glutamine synthetase and the glutamate synthase (GOGAT). The glutamate dehydrogenases are devoted to glutamate degradation in vivo. To keep the cellular glutamate concentration high, the genes and the encoded enzymes involved in glutamate biosynthesis and degradation need to be tightly regulated depending on the available carbon and nitrogen sources.