Keenan A. Lacey

Jul 24, 2024 | science.org | Keenan A. Lacey |Rui Liu |Long Huang |Wei Hu

AbstractDesigning highly efficient orally administrated nanotherapeutics with specific inflammatory site–targeting functions in the gastrointestinal tract for ulcerative colitis (UC) management is a noteworthy challenge. Here, we focused on exploring a specific targeting oral nanotherapy, serving as “one stone,” for the directed localization of inflammation and the regulation of redox homeostasis, thereby achieving effects against “two birds” for UC treatment.

Jul 24, 2024 | science.org | Keenan A. Lacey |Rui Liu |Hong liu |Jiantong Dong

AbstractAn ortho-nitrobenzyl phosphate ester–caged nucleic acid hairpin structure coupled to the CRISPR-Cas12a complex is introduced as a functional reaction module for the light-induced activation of the CRISPR-Cas12a (LAC12a) machinery toward the amplified fluorescence detection of microRNA-21 (miRNA-21). The LAC12a machinery is applied for the selective, in vitro sensing of miRNA-21 and for the intracellular imaging of miRNA-21 in different cell lines.

Jul 17, 2024 | science.org | Keenan A. Lacey |Rui Liu |Simon Cullen |Daniel Oppenheimer

AbstractDespite strong evidence that autonomy enhances motivation and achievement, few interventions for promoting student autonomy in higher education have been developed and empirically tested. Here, we demonstrate how two autonomy-supportive policies effectively increase classroom attendance and subject mastery.