Kelly Kersten

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Tumor-associated macrophages restrict CD8+ T cell function through collagen deposition and metabolic reprogramming of the breast cancer microenvironment | Nature Cancer

Jun 3, 2024 | nature.com | Kelly Kersten |Ori Maller |Greg A. Timblin |Mary-Kate Hayward |Bushra Samad |Alexander Muir | +2 more

AbstractTumor progression is accompanied by fibrosis, a condition of excessive extracellular matrix accumulation, which is associated with diminished antitumor immune infiltration. Here we demonstrate that tumor-associated macrophages (TAMs) respond to the stiffened fibrotic tumor microenvironment (TME) by initiating a collagen biosynthesis program directed by transforming growth factor-β.

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