Kennedy Tower

May 3, 2024 | onlinelibrary.wiley.com | Damien Wright |Kennedy Tower |Aisling Kenny |Sarah J. Eley

INTRODUCTION SYNGAP1-related intellectual disability (hereafter SYNGAP1-ID) is a neurodevelopmental disorder caused by pathological variation of the SYNGAP1 gene. Truncating mutations are the most commonly reported in the literature, though others including missense and microdeletions have also been described (Berryer et al., 2013).

May 1, 2023 | bmcpsychiatry.biomedcentral.com | NHS Lothian |Kennedy Tower |Morningside Terrace

ParticipantsThis study used data from the LBC1936 (https://www.ed.ac.uk/lothian-birth-cohorts), described in detail elsewhere [7,8,9]. In summary, participants living in the Lothian region of Scotland (which includes Edinburgh), most of whom had completed an intelligence test aged 11 years, were recruited in 2004, at mean age 69.5 years (n = 1091). At initial recruitment, none reported a diagnosis of dementia, this was a specific inclusion criterion of the LBC1936.