Kenneth W. Mahaffey

Nov 11, 2023 | jamanetwork.com | Kenneth W. Mahaffey |C. Michael Gibson |Renato D. Lopes

Systematic, standardized, and independent assessment of clinical trial end points is critical to protect the scientific integrity of clinical trials.1 Clinical event classification (CEC) has become the criterion standard for the process of event adjudication, which includes the creation of end point definitions; the identification of suspected events; the collection of information through dedicated case report forms, collection of medical records, and access to ancillary or administrative...

Jun 13, 2023 | drc.bmj.com | David M. Charytan |Kenneth W. Mahaffey |Meg Jardine |Christopher Cannon

DiscussionIn this post hoc analysis of the CREDENCE study, we demonstrated that the glycemic effects of canagliflozin were modified by baseline eGFR, with a progressively lesser reduction and lower likelihood of achieving a >0.5% decrease in HbA1c across CKD stages G1-2 (eGFR >60 mL/min/1.73 m2), stage G3A (eGFR 45–60 mL/min/1.73 m2), and stage 3B (eGFR 30–44 mL/min/1.73 m2).