Kevin Costa

Oct 4, 2023 | biorxiv.org | David Sachs |Kevin Costa

AbstractDeveloping a novel microfluidic organoid system required many experiments and iterations due to lack of knowledge about the relevant developmental biology. Collecting data on the developing organoids quickly escalated into a bottleneck as high throughput and long term culture resulted in a rapidly increasing number of specimens being observed. Commercially available automated microscope systems exist, but were either too expensive or not appropriate, and could not be modified.

Oct 4, 2023 | biorxiv.org | David Sachs |Kevin Costa

AbstractWhile many cell culture systems are sensitive to the conditions in which cells are introduced into the system, we find that in situ differentiated tube-shaped microfluidic organoids have a particularly high sensitivity. Preliminary experiments using conventional seeding techniques revealed that biases in initial cell number and distribution dramatically impacted organoid shape and behavior downstream.

Oct 4, 2023 | biorxiv.org | Robert Wiener |Kevin Costa

AbstractMarfan Syndrome (MFS), a connective tissue disorder caused by a mutation in the fibrillin-1 gene, occurs in approximately 1 in 5,000 people worldwide. As an important constituent of the extracellular matrix, mutated fibrillin-1 in Marfan Syndrome leads to aortic medial degeneration, aneurysm, and dissection. TGFβ in the matrix, which is controlled by fibrillin-1, is known to cause pathological effects in smooth muscle cells (SMCs) within the aortic wall during MFS.

Sep 20, 2023 | sooperarticles.com | Kevin Costa

Web design is a multidisciplinary field that creates visually appealing and user-friendly websites by combining aspects of art, psychology, and functionality. The creation and utilization of mood boards is one of the essential steps in the web design process. These visual collages are crucial in determining the creative direction and ensuring that the design is cohesive.

Sep 13, 2023 | sooperarticles.com | Kevin Costa

In the digital age, marketing strategies are constantly evolving to keep up with the ever-changing customer landscape. The fuse of computerized reasoning (man-made intelligence) with generative capacities into advertising procedures is quite possibly of the main improvement lately. Generative artificial intelligence, including content turn of events, personalization, client association, and that's only the tip of the iceberg, has proactively changed various parts of the promoting area.