Kévin Nuno

Apr 22, 2024 | elifesciences.org | Kévin Nuno |Armon Azizi |Thomas Koehnke |Caleb A Lareau

Editor's evaluation The authors show convincingly that most relapses in AML occur without changes in driver mutations. By using ATAC-seq in matched diagnosis and relapsed samples, they show that epigeneticc mechanisms drive relapse in a large proportion of cases. These findings are of translational importance and are based on rigorous analysis of large set of primary samples.

Oct 10, 2023 | biorxiv.org | Kévin Nuno |Armon Azizi |Caleb A Lareau |Thomas Koehnke

AbstractRelapse of acute myeloid leukemia (AML) is highly aggressive and often treatment refractory. We analyzed previously published AML relapse cohorts and found that 40% of relapses occur without changes in driver mutations, suggesting that non-genetic mechanisms drive relapse in a large proportion of cases. We therefore characterized epigenetic patterns of AML relapse using 26 matched diagnosis-relapse samples with ATAC-seq.