Kheireddin Mufti

Nov 4, 2024 | nature.com | Kheireddin Mufti |Catrina M. Loucks |Shahrad R. Rassekh |Bruce C Carleton

AbstractVincristine-induced peripheral neuropathy is a common and highly debilitating toxicity from vincristine treatment that affects quality of life and often requires dose reduction, potentially affecting survival. Although previous studies demonstrated genetic factors are associated with vincristine neuropathy risk, the clinical relevance of most identified variants is limited by small sample sizes and unclear clinical phenotypes.