Kinya Otsu

Aug 14, 2024 | nature.com | Tingting Zheng |Kinya Otsu

AbstractPsoriasis is characterized by keratinocyte (KC) hyperproliferation and inflammatory cell infiltration, but the mechanisms remain unclear. In an imiquimod-induced mouse psoriasiform model, p38 activity is significantly elevated in KCs and p38α specific deletion in KCs ameliorates skin inflammation. p38α signaling promotes KC proliferation and psoriasis-related proinflammatory gene expression during psoriasis development.

Sep 13, 2023 | kcl.ac.uk | Kinya Otsu

Research into an enzyme involved in necrosis (uncontrolled cell death) has uncovered a new mechanism that could form the basis of new therapies against heart failure. A biological mechanism in the heart’s muscle cells has been linked to one of the main causes of heart failure, opening up possibilities for future treatments. As part of the study, which was published in Nature Communications, researchers removed a specific enzyme located in cardiac muscle cells from mice.