Kirsten Harvey

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Transcriptomics and weighted protein network analyses of the LRRK2 protein interactome reveal distinct molecular signatures for sporadic and LRRK2 Parkinson’s Disease | npj Parkinson's Disease

Aug 2, 2024 | nature.com | Yibo Zhao |Kirsten Harvey |Patrick Lewis

AbstractMutations in the LRRK2 gene are the most common genetic cause of familial Parkinson’s Disease (LRRK2-PD) and an important risk factor for sporadic PD (sPD). Multiple clinical trials are ongoing to evaluate the benefits associated with the therapeutical reduction of LRRK2 kinase activity.

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