Kiseok Keith Lee

Feb 29, 2024 | biorxiv.org | Rita Oliveira |Bipul Pandey |Kiseok Keith Lee |Mahmoud Yousef

AbstractMicrobiomes perform critical functions across many environments on Earth1,2,3. However, elucidating principles of their design is immensely challenging4,5,6,7. Using a diverse bank of human gut commensal strains and clearance of multi-drug resistant Klebsiella pneumoniae as a target, we engineered a functional synthetic microbiome using a process that was agnostic to mechanism of action, bacterial interactions, or compositions of natural microbiomes.