Kodai Sakiyama

Jan 1, 2024 | jrheum.org | Kodai Sakiyama |Michihito Kono |Ai Shimizu |Tatsuya Atsumi

Patients with Sjögren syndrome (SS) have a higher risk of developing malignant lymphoma.1A 68-year-old woman presented with a 2-month history of swollen parotid glands. The patient had psoriatic arthritis and had been treated with secukinumab for 3 months. At presentation, she had bilateral swollen and ulcerated parotid glands (Figure 1A) with sicca symptoms. Laboratory data showed positivity for anti-SSA and anti-SSB antibodies and elevated C-reactive protein (15.2 mg/L).

Feb 27, 2023 | nature.com | Kuniyuki Aso |Michihito Kono |Kodai Sakiyama |Daigo Nakazawa |Masaru Kato

AbstractDysregulation of Th17 and Treg cells contributes to the pathophysiology of many autoimmune diseases. Herein, we show that itaconate, an immunomodulatory metabolite, inhibits Th17 cell differentiation and promotes Treg cell differentiation by orchestrating metabolic and epigenetic reprogramming. Mechanistically, itaconate suppresses glycolysis and oxidative phosphorylation in Th17- and Treg-polarizing T cells.