Kohjin Suzuki

Dec 9, 2024 | onlinelibrary.wiley.com | Kohjin Suzuki |Naoki Watanabe |Satoru Torii |Satoko Arakawa

1 INTRODUCTION The Philadelphia chromosome results from a translocation between chromosomes 9 and 22, generating the BCR::ABL1 fusion gene.1, 2 ABL1 is a tyrosine kinase involved in cellular proliferation signaling; the BCR::ABL1 fusion gene leads to the constant activation of ABL1, initiating aberrant cellular proliferation.3 The Philadelphia chromosome is considered central to CML pathogenesis and is currently its only therapeutic target.4, 5 However, despite significant improvements in the...

Jul 28, 2023 | biorxiv.org | Naoki Watanabe |Satoru Torii |Satoko Arakawa |Kohjin Suzuki

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