Koichiro Irie

Aug 16, 2024 | science.org | Leandro P. Araujo |Andrew Patterson |Madeline Edwards |Koichiro Irie

Editor’s summaryGroup 3 innate lymphoid cells (ILC3s) contribute to intestinal homeostasis and immunity against gut pathogens. Distinguishing the functions of ILC3s from those of T helper 17 (TH17) cells has remained challenging because of similar transcription factor dependencies and cytokine production profiles. To better define ILC3-specific roles, Araujo et al. developed genetically engineered mice that lack ILC3s while retaining endogenous T cells and secondary lymphoid organs.