Konda Mani Saravanan

Nov 4, 2024 | biorxiv.org | Seithikurippu R Pandi-Perumal |Konda Mani Saravanan |Sayan Paul |George Abraham

AbstractSleep is a widespread and evolutionarily conserved process observed in diverse organisms, from jellyfish to mammals, hinting at its origin as a life-supporting mechanism over 500 million years ago. Although its fundamental purpose and mechanisms remain unclear, the evolution and adaptive significance of sleep continue to be debated.

Nov 4, 2024 | biorxiv.org | Seithikurippu R Pandi-Perumal |Konda Mani Saravanan |Sayan Paul

AbstractSleep is a universally conserved behavior with an elusive origin and an uncertain evolutionary purpose. Leveraging phylogenomics, we investigate the evolutionary foundations of sleep by identifying orthologs of Human sleep-related genes in the Lokiarchaeota of the Asgard superphylum. Our findings indicate a conserved suite of genes associated with energy metabolism and cellular repair, suggesting a primordial role of sleep in cellular maintenance.