Krista Mills

Apr 1, 2024 | cell.com | Krista Mills |Joseph J. Maciag |Can Wang |John Crawford

Highlights•There are two major divergent SasG alleles in S. aureus, SasG-I and SasG-II•SasG-II contains a nonaromatic arginine residue in the lectin-binding pocket•SasG-II has a different adhesion profile than SasG-I and binds a broader variety of ligandsSummaryStaphylococcus aureus causes the majority of skin and soft tissue infections, but this pathogen only transiently colonizes healthy skin. However, this transient skin exposure enables S. aureus to transition to infection.

Nov 21, 2023 | biorxiv.org | Krista Mills |Joseph J. Maciag |Can Wang |John Crawford

AbstractStaphylococcus aureus causes the majority of skin and soft tissue infections, but this pathogen only transiently colonizes healthy skin. However, this transient skin exposure enables S. aureus to transition to infection. Initial adhesion of S. aureus to skin corneocytes is mediated by surface protein G (SasG). Here, phylogenetic analyses reveal the presence of two major divergent SasG alleles in S. aureus, SasG-I and SasG-II.