Kuniyuki Aso

Jul 13, 2023 | ard.bmj.com | Kuniyuki Aso |Yuichiro Fujieda |Tatsuya Atsumi

http://orcid.org/0000-0001-8601-6377Kuniyuki Aso, http://orcid.org/0000-0003-4705-341XYuichiro Fujieda, Tatsuya Atsumi Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Japan Correspondence to Dr Yuichiro Fujieda, Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan; edaichi{at}med.hokudai.ac.jp...

Feb 27, 2023 | nature.com | Kuniyuki Aso |Michihito Kono |Kodai Sakiyama |Daigo Nakazawa |Masaru Kato

AbstractDysregulation of Th17 and Treg cells contributes to the pathophysiology of many autoimmune diseases. Herein, we show that itaconate, an immunomodulatory metabolite, inhibits Th17 cell differentiation and promotes Treg cell differentiation by orchestrating metabolic and epigenetic reprogramming. Mechanistically, itaconate suppresses glycolysis and oxidative phosphorylation in Th17- and Treg-polarizing T cells.