Kyoto Prefectural

Jan 23, 2025 | link.springer.com | Kyoto Prefectural

AbstractInguinal endometriosis is a less common form of endometriosis. Therefore, there is no consensus regarding its pathogenesis or treatment. In this study, we retrospectively reviewed the pathogenesis and treatment of six cases of inguinal endometriosis in our facility between 2009 and 2019. The pathogenesis of inguinal endometriosis is believed to involve hematogenous and lymphogenous extensions, as well as direct infiltration from the canal of Nuck or inguinal hernia.

Nov 29, 2024 | academic.oup.com | Kyoto Prefectural

The Phase 3 INDIGO study (NCT04164901) evaluated vorasidenib, an oral, brain-penetrant, dual inhibitor of mutated isocitrate dehydrogenase 1/2 (mIDH1/2), in patients with mIDH1/2 diffuse glioma. The primary endpoint of progression-free survival (PFS) per blinded independent review committee (BIRC) and key secondary endpoint of time to next intervention (TTNI) were met in the second interim analysis. In March 2023, the study was unblinded following committee recommendation.

Nov 13, 2024 | arthritis-research.biomedcentral.com | Kyoto Prefectural

This cross-sectional study used data acquired through a multidisciplinary cohort study (the Lupus Registry of Nationwide Institutions [LUNA]) conducted in 2016 to investigate the association between clinical manifestations, socioeconomic backgrounds, and outcomes of patients with SLE reported from 14 Japanese institutions. Approximately 2.3% of patients with SLE in Japan have been registered in the LUNA, accounting for approximately 1,500 cases.

Nov 7, 2024 | giejournal.org | Kyoto Prefectural

1Department of Internal Medicine, Masuko Memorial Hospital, Nagoya, Department of Advanced Endoscopy, Fujita Health University School of Medicine, Toyoake, Japan 2Departments of Gastroenterology and Advanced Endoscopy, Fujita Health University School of Medicine, Toyoake, Japan 3Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan 4Endoscopy Center, Aishinkai Nakae Hospital, Wakayama, Japan 5Endoscopic and Photodynamic Medicine,...

Nov 1, 2024 | jintensivecare.biomedcentral.com | Kyoto Prefectural

In phage therapy, practitioners utilize two types of phages: naturally occurring phages and artificially modified phages. Numerous ventures have been established worldwide to advance phage development. These companies are actively engaged in projects aimed at developing engineered phages that exhibit a broader spectrum of activity against diverse bacterial strains, remove superfluous phage proteins that may pose safety concerns, and increase the stability of their bactericidal properties.